Hyperpolarized [1-13C]pyruvate MRI is an exciting emerging clinical tool for metabolic imaging. It has the potential for absolute quantitative metabolic imaging. However, in contrast to the most abundant metabolic imaging techniques, the signal itself is less quantitative by nature and, thus the most abundant analyses are relative or semiquantitative. Here, we propose a simple normalization to the whole body metabolic oxidative metabolism to overcome this limitation.
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