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Abstract #2424

Hyperpolarising 13C-glucose with an endogenous labile photoinduced radical

Jennifer Lewis1, Adam Gaunt1, Irene Marco-Rius1, and Arnaud Comment1,2
1Cambridge University, Cambridge, United Kingdom, 2General Electric Healthcare, Chalfont St Giles, United Kingdom


The use of the endogenous molecule alpha-ketoglutarate (α-KG) as a non-persistent radical is examined to hyperpolarise 13C-glucose. A radical build-up curve was obtained and the maximum radical concentration was calculated to be 29 ± 3 mM. The microwave irradiation frequency was then examined to optimise the polarisation transfer between the electron on α-KG and glucose. A dissolution was successfully carried out and a hyperpolarised 13C spectrum of 13C-glucose was obtained.

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