The sensitivity of diffusion MRI (dMRI) towards microstructural features is quite high, but its specificity is low due to the ubiquity of water in biological tissues. Here, we harness a strongly filtered diffusion kurtosis imaging (DKI) approach to (i) suppress fast diffusion spins typically associated with extracellular space and (ii) measure the time dependencies of the full filtered diffusion and kurtosis tensors in an ex-vivo mouse brain at 16.4T. Following the application of a very strong filter of b1=15ms/µm2 perpendicular to axon fibers, we find signatures for restricted diffusion that are tentatively associated with intracellular space.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords