Meeting Banner
Abstract #2428

Time dependence of the diffusion and kurtosis tensors in strongly filtered diffusion signals  

Noam Shemesh1, Andrada Ianus1, and Sune N Jespersen2,3
1Champalimaud Centre for the Unknown, Lisbon, Portugal, 2Center for Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, 3Department of Physics and Astronomy, Aarhus University, Aarhus, Denmark


The sensitivity of diffusion MRI (dMRI) towards microstructural features is quite high, but its specificity is low due to the ubiquity of water in biological tissues. Here, we harness a strongly filtered diffusion kurtosis imaging (DKI) approach to (i) suppress fast diffusion spins typically associated with extracellular space and (ii) measure the time dependencies of the full filtered diffusion and kurtosis tensors in an ex-vivo mouse brain at 16.4T. Following the application of a very strong filter of b1=15ms/µm2 perpendicular to axon fibers, we find signatures for restricted diffusion that are tentatively associated with intracellular space.

This abstract and the presentation materials are available to members only; a login is required.

Join Here