Abstract #2456
Diffusion metrics in human white matter depend on fiber orientation
Lara Bartels1,2,3, Jonathan Doucette1,2,3, Christoph Birkl2,4, Alexander M. Weber2,3, and Alexander Rauscher1,2,3,5,6
1Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, 2MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, 3Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada, 4Department of Neuroradiology, Medical University of Innsbruck, Innsbruck, Austria, 5Department of Radiology, University of British Columbia, Vancouver, BC, Canada, 6Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada
Synopsis
In this work we studied the orientation dependence of diffusivities measured in DTI of healthy human white matter in vivo. The observed orientation dependence of the mean diffusivity can be explained by the effects of diffusion-mediated dephasing in the presence of diamagnetic myelin. Orientation dependence was markedly different for the radial and axial components of the diffusivity and suggests the presence of residual dipole-dipole interaction between water molecules.
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