Abstract #2456

Diffusion metrics in human white matter depend on fiber orientation

Lara Bartels^1,2,3, Jonathan Doucette^1,2,3, Christoph Birkl^2,4, Alexander M. Weber^2,3, and Alexander Rauscher^1,2,3,5,6

¹Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, ²MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, ³Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada, ⁴Department of Neuroradiology, Medical University of Innsbruck, Innsbruck, Austria, ⁵Department of Radiology, University of British Columbia, Vancouver, BC, Canada, ⁶Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada

Synopsis

In this work we studied the orientation dependence of diffusivities measured in DTI of healthy human white matter in vivo. The observed orientation dependence of the mean diffusivity can be explained by the effects of diffusion-mediated dephasing in the presence of diamagnetic myelin. Orientation dependence was markedly different for the radial and axial components of the diffusivity and suggests the presence of residual dipole-dipole interaction between water molecules.

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