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Abstract #2457

Detection of Iron Oxide Nanoparticles (IONPs)-Labeled Stem Cells Using Quantitative UTE Imaging

Jiyo S Athertya1, Johnny Akers2, Sophia Dwek1, Zhao Wei1, Jiang Du1, Eric Y Chang1,3, Mya Thu2, and Hyungseok Jang1
1Radiology, University of California San Diego, San Diego, CA, United States, 2VisiCELL Medical Inc, San Diego, CA, United States, 3Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States


Non-invasive, clinically applicable tracking of therapeutic cells by magnetic resonance imaging (MRI) offers unparalleled insight into the safety and efficacy of cell-based therapies in the body. Here we used a series of 3D quantitative UTE techniques including UTE-QSM, UTE-T1, and UTE-T2* mapping to evaluate the MR characteristics of stem cells labeled with a proprietary nanoparticle formulation that simultaneously labels cells for both optical and MR imaging. In a phantom experiment, all quantitative UTE parameters showed strong correlation with concentrations of labeled stem cells. Interestingly, in ex vivo mouse imaging, only UTE-QSM and UTE-T2* mapping detected the injected, labeled stem cells.

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