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Abstract #2459

The impact of head orientation with respect to B0: An unexplored source of variance in diffusion MRI

Elena Kleban1,2, Derek K Jones1,3, and Chantal MW Tax1,4
1CUBRIC, Cardiff University, Cardiff, United Kingdom, 2Inselspital, Bern University, Bern, Switzerland, 3Australian Catholic University, Melbourne, Australia, 4UMC Utrecht, Utrecht University, Utrecht, Netherlands


Recently observed anisotropy of compartmental white matter T2-values as a function of tissue orientation w.r.t. B0 in combination with echo-time-dependence of diffusion MRI signals suggest that similar tissue-orientational effects could be expected in standard diffusion tensor measures. In this work we show the change of up to 20-30% in diffusion tensor measures as a function of fibre orientation w.r.t. B0 from in vivo experiments and support these observations by simplified two-compartment white matter signal simulations.

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