Tissue magnetic susceptibility maps calculated using any Quantitative Susceptibility Mapping (QSM) pipeline are often corrupted by streaking artifacts. Large streaking artifacts originating from extreme-susceptibility regions, such as interhemispheric calcifications or intracerebral bleeds, are common, not only in patients, but also in healthy, elderly subjects. Several variations on the two-pass masking approach have been proposed previously to suppress these artifacts. Here we propose a broadly-applicable two-pass masking method that is easy to implement and integrate into any QSM pipeline. We show that two-pass masking greatly reduces streaking from calcifications and cerebral bleeds without affecting susceptibility map anatomical features and values.
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