Abstract #2465

QALAS + QSM: Efficient Multi-parameter Mapping Allows Disentangling Para- and Dia-magnetic Contributions in Brain Tissue

Hyeong-Geol Shin¹, Jingjia Chen², Jongho Lee¹, Tae Hyung Kim³, Jaejin Cho³, Gabriel Varela-Mattatall³, Borjan Gagoski⁴, Chunlei Liu², and Berkin Bilgic³

¹Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea, Republic of, ²Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley, CA, United States, ³Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ⁴Fetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children’s Hospital, Boston, MA, United States

Synopsis

Quantitative MRI has demonstrated potential in clinical and neuroscience applications, but its adoption has been hampered by excessively long scan times. Recent biophysical models have enabled differentiation of para- and dia-magnetic contributions to the tissue, but the acquisition of multi-parametric maps required by such models have further increased the encoding burden. We propose a comprehensive 9.5 min exam at high isotropic resolution to address this, from which T1, T2, proton density, T2*, para- and dia-magnetic susceptibility maps are estimated. This exam flexibly lends itself to generation of contrast-weighted images, allowing it to be used for clinical reads as well.

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