Quantitative MRI has demonstrated potential in clinical and neuroscience applications, but its adoption has been hampered by excessively long scan times. Recent biophysical models have enabled differentiation of para- and dia-magnetic contributions to the tissue, but the acquisition of multi-parametric maps required by such models have further increased the encoding burden. We propose a comprehensive 9.5 min exam at high isotropic resolution to address this, from which T1, T2, proton density, T2*, para- and dia-magnetic susceptibility maps are estimated. This exam flexibly lends itself to generation of contrast-weighted images, allowing it to be used for clinical reads as well.
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