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Abstract #2466

On the water–fat in-phase assumption for quantitative susceptibility mapping (QSM)

Christof Boehm1, Jakob Meineke2, Kilian Weiss3, Marcus R Makowski1, and Dimitrios C Karampinos1
1Department of Diagnostic and Interventional Radiology, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany, 2Philips Research, Hamburg, Germany, 3Philips GmbH Market DACH, Hamburg, Germany


Gradient echo imaging using in-phase echoes has been proposed to reduce the field-map estimation in water–fat regions to a convex nonlinear least squares problem. Conventionally, the in-phase assumption is based on a single-peak fat-model. However, fat is known to have a complex spectrum rendering the definition of in-phase echo times problematic. In this work, the single-fat-peak in-phase assumption is replaced by a multi-peak effective in-phase assumption. QSM based on multi-peak in-phase echo times is shown to yield similar results to water–fat imaging based field- and susceptibility-mapping in a simulation and in vivo in the spine and the breast.

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