Patients with type 2 diabetes mellitus (T2DM) often have pathologically altered lipid metabolism. Evidence has confirmed that dyslipidemia is linked to cognitive decline. We explored the large-scale functional network connectivity alterations and their potential relationships with serum lipids and cognitive performance in T2DM patients. Our results suggested lower inter and intra-network functional connectivity in T2DM patients and the possibility of improving cognitive function through lipids management.
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