Abstract #2478

Brainwide functional networks associated with hippocampal subfields during memory task using fMRI with 1-mm isotropic resolution

Wei-Tang Chang^1,2, Stephanie Langella³, Khoi Huynh², Min Sung Seo⁴, Pew-Thian Yap², Weili Lin², and Kelly Sullivan Giovanello⁴

¹Radiology, UNIV OF NORTH CAROLINA AT CHAPEL HILL, Chapel Hill, NC, United States, ²BRIC, UNIV OF NORTH CAROLINA AT CHAPEL HILL, Chapel Hill, NC, United States, ³Martinos center, Massachusetts General Hospital, Charlestown, MA, United States, ⁴Psychology, UNIV OF NORTH CAROLINA AT CHAPEL HILL, Chapel Hill, NC, United States

Synopsis

The interactions between the hippocampal subfields (HCSFs) and cerebral cortex during memory are unclear due to the inherently-low SNR, insufficient spatial resolution or limited spatial coverage. This study is the first fMRI study to examine how the HCSFs interact with the entire cortical surface during the memory encoding and retrieval process by addressing the above-mentioned issues successfully. Our results suggested that 1) the cortical-HCSF functional connectivity (FC) during encoding generally decreased compared to resting, 2) the cortical-HCSF FC increased compared to encoding during retrieval; 3) stronger FC between posterior CA1 and dorsal attention network are correlated with better behavioural performance.

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