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Abstract #2486

Evaluating renal fibrosis in a nephrotoxic nephritis model using DTI-MRI

Shimrit Avraham1, Rohan Virgincar2, Joshua Webster3, Andrey Shaw1, and Luke Xie2
1Research Biology, Genentech, South San Francisco, CA, United States, 2Biomedical Imaging, Genentech, South San Francisco, CA, United States, 3Research Pathology, Genentech, South San Francisco, CA, United States


Accurate estimation of kidney function is crucial to the detection, evaluation, and treatment of chronic kidney disease (CKD). The traditional methods are inaccurate or invasive. Here, we used DTI-MRI to evaluate kidney function with disease progression in nephrotoxic serum- induced CKD model (NTN). We detect changes associated with renal inflammation and fibrosis prior to functional decline. Moreover, AD and ADC of the cortex-outer medulla border were highly correlated with histologic evidence of fibrosis. These results suggest that DTI-MRI can detect early stages of CKD non-invasively in-vivo and can be used for fibrosis mapping in a variety of renal diseases.

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