Abstract #2492
Parametric T1 MR Microscopy Detects Gadolinium Residuals in Ex Vivo Rat Kidneys
Ehsan Tasbihi1, Luis Hummel2, Thomas Gladytz1, Ludger Starke1, Jason M. Millward1, Erdmann Seeliger2, and Thoralf Niendorf1,3
1Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, Berlin, Germany, 2Institute of Vegetative Physiology, Charité – Universitätsmedizin Berlin, Berlin, Germany, Berlin, Germany, 3Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the MAX Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, Berlin, Germany
Synopsis
Accumulation of gadolinium (Gd) following use of Gd-based contrast agents (GBCA) is a concern. To study the potential of T1 microscopy for assessing Gd residues in the kidney, rats were administered 8 intravenous doses of various GBCAs over a period of two weeks. Five days following the last administration, the kidneys were collected and fixed in formalin. High resolution T1 maps obtained from ex vivo scans showed significantly reduced T1 levels for both linear and macrocyclic GBCAs. This demonstrates to potential for quantitative T1 mapping to detect Gd residues non-invasively in renal tissue.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
