Abstract #2498

Tumor infiltration beyond contrast enhancement and FLAIR hyperintensity at autopsy predicts survival in glioblastoma patients

Samuel Bobholz¹, Allison Lowman², Michael Brehler², Savannah Duenweg¹, John Sherman¹, Fitzgerald Kyereme², Elizabeth Cochran³, Dylan Coss³, Jennifer Connelly⁴, Wade Mueller⁵, Mohit Agarwal², Anjishnu Banerjee⁶, and Peter LaViolette^2,7

¹Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States, ²Radiology, Medical College of Wisconsin, Milwaukee, WI, United States, ³Pathology, Medical College of Wisconsin, Milwaukee, WI, United States, ⁴Neurology, Medical College of Wisconsin, Milwaukee, WI, United States, ⁵Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States, ⁶Biostatistics, Medical College of Wisconsin, Milwaukee, WI, United States, ⁷Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI, United States

Synopsis

This study compared autopsy tissue samples to clinical MRI from glioblastoma (GBM) patients to assess the effects of tumor outside of T1-contrast enhancement and FLAIR hyperintensity on clinical characteristics and outcomes. Non-enhancing tumors were more frequent amongst patients who had a history of bevacizumab treatment and no history of Tumor Treating Fields treatment. Additionally, non-enhancing tumors were associated with shorter overall survival times. These results suggest that non-enhancing tumors have clinically significant correlates and may result in worse survival outcomes for GBM patients.

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