Abstract #2499

Structural disconnections in brain tumours: investigating the similarity of Direct and Indirect Approaches

Umberto Villani^1,2, Erica Silvestri^1,2, Manuela Moretto^1,2, Maria Colpo^1,2, Alessandro Salvalaggio^1,3, Maurizio Corbetta^1,3,4, Diego Cecchin^1,5, and Alessandra Bertoldo^1,2

¹Padova Neuroscience Center, University of Padova, Padova, Italy, ²Department of Information Engineering, University of Padova, Padova, Italy, ³Department of Neuroscience, University of Padova, Padova, Italy, ⁴Venetian Institute of Molecular Medicine, Padova, Italy, ⁵Department of Medicine, Unit of Nuclear Medicine, University of Padova, Padova, Italy

Synopsis

Gliomas are amongst the most common primary brain tumours in adults and are often associated with poor prognosis. Understanding the extent of white matter (WM) which is affected outside the tumoral lesion may be of paramount importance to explain cognitive deficits and the clinical progression of the disease. Thus, we apply both direct (i.e., tractography based) and indirect (i.e., atlas based) approaches to quantifying WM structural disconnections in a cohort of 50 glioma patients. We eventually compare the disconnections maps provided by the two methodologies in terms of spatial similarity and discuss their critical use in this field.

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