Structural disconnections in brain tumours: investigating the similarity of Direct and Indirect Approaches
Umberto Villani1,2, Erica Silvestri1,2, Manuela Moretto1,2, Maria Colpo1,2, Alessandro Salvalaggio1,3, Maurizio Corbetta1,3,4, Diego Cecchin1,5, and Alessandra Bertoldo1,2
1Padova Neuroscience Center, University of Padova, Padova, Italy, 2Department of Information Engineering, University of Padova, Padova, Italy, 3Department of Neuroscience, University of Padova, Padova, Italy, 4Venetian Institute of Molecular Medicine, Padova, Italy, 5Department of Medicine, Unit of Nuclear Medicine, University of Padova, Padova, Italy
Gliomas are amongst the most common primary brain tumours in adults and are often associated with poor prognosis. Understanding the extent of white matter (WM) which is affected outside the tumoral lesion may be of paramount importance to explain cognitive deficits and the clinical progression of the disease. Thus, we apply both direct (i.e., tractography based) and indirect (i.e., atlas based) approaches to quantifying WM structural disconnections in a cohort of 50 glioma patients. We eventually compare the disconnections maps provided by the two methodologies in terms of spatial similarity and discuss their critical use in this field.
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