Abstract #2502

Inhomogeneous MT (ihMT) MRI in a glioblastoma mouse model

Gopal Varma¹, Alan T Yeo^2,3, Cody Callahan^1,4, David C Alsop¹, Aaron K Grant¹, and Alain Charest^2,5

¹Division of MR Research, Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, ²Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, ³Sackler School of Graduate Studies, Tufts University School of Medicine, Boston, MA, United States, ⁴Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, ⁵Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States

Synopsis

Inhomogeneous MT (ihMT) MRI was applied in a genetic mouse model of glioblastoma to assess its potential to provide useful complementary information regarding the true extent of tumor infiltration. Data were acquired to produce maps of MT and ihMT ratios, which were analyzed based on regions of interest relative to brain tissue contralateral to the tumor and progression with time. The tumor was characterized by significantly lower MT and ihMT. Reduction in peripheral white matter ihMT was taken to indicate demyelinating processes associated with glioblastoma. Thus, ihMT might be used to inform on disease progression in tumor adjacent brain tissue.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.