Abstract #2502
Inhomogeneous MT (ihMT) MRI in a glioblastoma mouse model
Gopal Varma1, Alan T Yeo2,3, Cody Callahan1,4, David C Alsop1, Aaron K Grant1, and Alain Charest2,5
1Division of MR Research, Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, 2Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, 3Sackler School of Graduate Studies, Tufts University School of Medicine, Boston, MA, United States, 4Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, 5Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States
Synopsis
Inhomogeneous MT (ihMT) MRI was applied in a genetic mouse model of glioblastoma to assess its potential to provide useful complementary information regarding the true extent of tumor infiltration. Data were acquired to produce maps of MT and ihMT ratios, which were analyzed based on regions of interest relative to brain tissue contralateral to the tumor and progression with time. The tumor was characterized by significantly lower MT and ihMT. Reduction in peripheral white matter ihMT was taken to indicate demyelinating processes associated with glioblastoma. Thus, ihMT might be used to inform on disease progression in tumor adjacent brain tissue.
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