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Abstract #2503

Cost-Effectiveness Analysis of Diagnosis of Necrosis from Recurrent Tumor after RT with MRS, MRP and Combined Imaging Method for Low-Grade Glioma

Huijun Vicky Liao1, Raymond Y Huang2, Stella K Kang3, and Alexander Lin1
1Center for Clinical Spectroscopy, Brigham and Women's Hospital, Boston, MA, United States, 2Radiology, Brigham and Women's Hospital, Boston, MA, United States, 3Radiology, NYU Langone Medical Center, New York, NY, United States


Our decision-analytic model examined the cost-effectiveness of MR Spectroscopy (MRS), MR perfusion (MRP), and the combination of MRS, MRP and DWI for differentiating brain radiation necrosis from tumor progression in high-risk low-grade glioma. Our results suggested that performing combined imaging method had good diagnostic accuracy for a 3-year time horizon but not a cost-effective in the long run. In contrast, MRS and especially MRP alone were more cost-effective over all time horizons. MRS is the most cost-effective method in lifetime when its negative predictive value≥88% at the Willingness-to-Pay threshold of $100,000.

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