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Abstract #2511

Feasibility of Quantifying Cerebral Blood Volume and Blood-Brain Barrier Water Exchange using Non-Contrast MR Fingerprinting

Emma L Thomson1,2, Elizabeth Powell3, Claudia A M Gandini Wheeler-Kingshott2,4,5, and Geoff J M Parker1,2,6
1Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 2NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, London, United Kingdom, 3Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, 4Department of Brain & Behavioural Sciences, University of Pavia, Pavia, Italy, 5Brain Connectivity Centre Research Department, IRCCS Mondino Foundation, Pavia, Italy, 6Bioxydyn Limited, Manchester, United Kingdom


We propose the use of magnetic resonance fingerprinting (MRF), applied using a spoiled gradient echo sequence, to quantify cerebral blood volume ($$$\nu_b$$$) and inter-vascular water exchange (1/$$$\tau_b$$$), without the need for contrast agents. Through a simulation study we optimise a simulated acquisition protocol and test the sensitivity of the measurement, and its accuracy in the presence of variations in blood T1, tissue T1, and B1. We demonstrate that voxel-wise simultaneous quantification of $$$\nu_b ,\tau_b , T_{1,b}, T_{1,e}$$$ and $$$B_1^+$$$ is likely feasible with an optimised acquisition.

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