Abstract #2511

Feasibility of Quantifying Cerebral Blood Volume and Blood-Brain Barrier Water Exchange using Non-Contrast MR Fingerprinting

Emma L Thomson^1,2, Elizabeth Powell³, Claudia A M Gandini Wheeler-Kingshott^2,4,5, and Geoff J M Parker^1,2,6

¹Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ²NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, London, United Kingdom, ³Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, ⁴Department of Brain & Behavioural Sciences, University of Pavia, Pavia, Italy, ⁵Brain Connectivity Centre Research Department, IRCCS Mondino Foundation, Pavia, Italy, ⁶Bioxydyn Limited, Manchester, United Kingdom

Synopsis

We propose the use of magnetic resonance fingerprinting (MRF), applied using a spoiled gradient echo sequence, to quantify cerebral blood volume ($$$\nu_b$$$) and inter-vascular water exchange (1/$$$\tau_b$$$), without the need for contrast agents. Through a simulation study we optimise a simulated acquisition protocol and test the sensitivity of the measurement, and its accuracy in the presence of variations in blood T₁, tissue T₁, and B₁. We demonstrate that voxel-wise simultaneous quantification of $$$\nu_b ,\tau_b , T_{1,b}, T_{1,e}$$$ and $$$B_1^+$$$ is likely feasible with an optimised acquisition.

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