Measuring the macromolecular baseline in the neonatal brain
Maria Yanez Lopez1, Georg Oeltzschner2, Anthony N Price1, Nicolaas AJ Puts3, Emer J Hughes1, Grainne M McAlonan3, Tomoki Arichi1, Richard AE Edden2, and Enrico De Vita4
1Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom, 2Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom, 4Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King’s College London, London, UK, London, United Kingdom
The doublet nature of the 3 ppm peak previously reported in neonates indicates that a lower macromolecular contribution to the GABA+ 3 ppm signal is likely to be present in this population. Detailed characterisation of age‐related MM contribution rates is required to improve the MRS fitting process, and therefore, to further increase the accuracy of metabolic measurements in neonates. As a first step, we here measure the macromolecular baseline using metabolite-nulling MRS in healthy term neonatal participants.
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