Abstract #2535

Measuring the macromolecular baseline in the neonatal brain

Maria Yanez Lopez¹, Georg Oeltzschner², Anthony N Price¹, Nicolaas AJ Puts³, Emer J Hughes¹, Grainne M McAlonan³, Tomoki Arichi¹, Richard AE Edden², and Enrico De Vita⁴

¹Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom, ²Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom, ⁴Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King’s College London, London, UK, London, United Kingdom

Synopsis

The doublet nature of the 3 ppm peak previously reported in neonates indicates that a lower macromolecular contribution to the GABA+ 3 ppm signal is likely to be present in this population. Detailed characterisation of age‐related MM contribution rates is required to improve the MRS fitting process, and therefore, to further increase the accuracy of metabolic measurements in neonates. As a first step, we here measure the macromolecular baseline using metabolite-nulling MRS in healthy term neonatal participants.

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