Readout-Segmented COKE (RS-COKE) is an Echo Planar Spectroscopic Imaging (EPSI) variant supporting larger spectral-widths and is therefore useful for spectral imaging at 7T. However, mismatches between the segments at the overlaps lead to artifacts, especially if the lipids signal is not suppressed (to avoid adversely affecting the metabolites signal). We developed a procedure to measure and reduce the readout segment mismatches – through signal and trajectory corrections – leading to improved spectral images and spectra. The procedure was tested by scanning both a special 3D head-shaped phantom – which includes a lipid layer – and human volunteers.
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