Abstract #2537

GABA and Glutamate response to social processing; a functional MRS study

Duanghathai Pasanta^1,2, David J. White³, Jason L. He¹, Nicolaas A. Puts^1,4, and Talitha Ford^3,5

¹Department of Forensic and Neurodevelopmental Sciences, Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom, ²Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand, ³Centre for Human Psychopharmacology & Swinburne Neuroimaging, School of Health Sciences, Swinburne University of Technology, Melbourne, Australia, ⁴MRC Centre for Neurodevelopmental Disorders, King’s College London, London, United Kingdom, ⁵Cognitive Neuroscience Unit, Faculty of Health, Deakin University, Geelong, Australia

Synopsis

We performed functional magnetic resonance spectroscopy (fMRS) to measure the dynamic response of GABA and Glutamate in the superior temporal sulcus (STS) and visual cortex (V1) while viewing social stimuli. MEGA-PRESS fMRS spectra were analyzed in both block and event-related design. Sliding window analyses were used to investigate GABA and Glutamate dynamics at higher temporal resolution. A small decrease in GABA level was observed during stimulus presentation in V1, but no change was observed in STS. We highlight the feasibility of using fMRS to assess changes in metabolite response during social processing in health and disease.

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