Abstract #2538

Does Magnetic Resonance Spectroscopy Show Changes in Brain Metabolites At 3-Months Post Concussion in Pediatric Patients?

Robyn Walker¹, Parker La², Tiffany Bell ², Julie M Joyce ², Miriam Beauchamp^3,4, William Craig^5,6, Quynh Doan ^7,8, Roger Zemek^9,10, Keith Yeates ¹¹, and Ashley Harris²

¹University of Calgary, Calgary, AB, Canada, ²Radiology, University of Calgary, Calgary, AB, Canada, ³Psychology, University of Montreal, Montreal, QC, Canada, ⁴Psychology, Ste Justine Hospital, Montreal, QC, Canada, ⁵Pediatrics, University of Alberta, Edmonton, AB, Canada, ⁶Pediatrics, Stollery Children's Hospital, Edmonton, AB, Canada, ⁷Pediatrics, University of British Columbia, Vancouver, BC, Canada, ⁸Pediatrics, BC Children's Hospital, Vancouver, AB, Canada, ⁹Pediatrics and Emergency Medicine, University of Ottawa, Ottawa, ON, Canada, ¹⁰Pediatrics and Emergency Medicine, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada, ¹¹Psychology, University of Calgary, Calgary, AB, Canada

Synopsis

This study uses 1H magnetic resonance spectroscopy (MRS) to determine metabolite differences in the chronic phase (~3-month) of pediatric concussion compared to orthopedic injury (OI) controls. In the first analysis, significant differences in N-acetylaspartate (NAA), choline (Cho) and inositol (Ins) were seen between concussion and OI controls. Secondly, in a series of 3-way ANCOVAs across OI, symptomatic and asymptomatic concussion groups showed group differences in NAA, Cho and Ins depending on the symptom scale. When metabolites were different in this analysis by symptoms, it was generally driven by the asymptomatic group.

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