Does Magnetic Resonance Spectroscopy Show Changes in Brain Metabolites At 3-Months Post Concussion in Pediatric Patients?
Robyn Walker1, Parker La2, Tiffany Bell 2, Julie M Joyce 2, Miriam Beauchamp3,4, William Craig5,6, Quynh Doan 7,8, Roger Zemek9,10, Keith Yeates 11, and Ashley Harris2
1University of Calgary, Calgary, AB, Canada, 2Radiology, University of Calgary, Calgary, AB, Canada, 3Psychology, University of Montreal, Montreal, QC, Canada, 4Psychology, Ste Justine Hospital, Montreal, QC, Canada, 5Pediatrics, University of Alberta, Edmonton, AB, Canada, 6Pediatrics, Stollery Children's Hospital, Edmonton, AB, Canada, 7Pediatrics, University of British Columbia, Vancouver, BC, Canada, 8Pediatrics, BC Children's Hospital, Vancouver, AB, Canada, 9Pediatrics and Emergency Medicine, University of Ottawa, Ottawa, ON, Canada, 10Pediatrics and Emergency Medicine, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada, 11Psychology, University of Calgary, Calgary, AB, Canada
This study uses 1H magnetic resonance spectroscopy (MRS) to determine metabolite differences in the chronic phase (~3-month) of pediatric concussion compared to orthopedic injury (OI) controls. In the first analysis, significant differences in N-acetylaspartate (NAA), choline (Cho) and inositol (Ins) were seen between concussion and OI controls. Secondly, in a series of 3-way ANCOVAs across OI, symptomatic and asymptomatic concussion groups showed group differences in NAA, Cho and Ins depending on the symptom scale. When metabolites were different in this analysis by symptoms, it was generally driven by the asymptomatic group.
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