Abstract #2561
Impact of capillary transit time heterogeneity on resting-state BOLD-FC in patients with unilateral asymptomatic carotid artery stenosis
Sebastian Constantin Schneider1,2, Mario Eduardo Archila-Meléndez1,2, Jens Göttler1,2, Stephan Kaczmarz1,2,3, Jan Kufer1,2, Benedikt Zott1,2, Josef Priller4, Michael Kallmayer5, Claus Zimmer1, Christian Sorg1,2, and Christine Preibisch1,2,6
1School of Medicine, Klinikum rechts der Isar, Department of Diagnostic and Interventional Neuroradiology, Technical University of Munich, Munich, Germany, 2School of Medicine, Klinikum rechts der Isar, TUM Neuroimaging Center, Technical University of Munich, Munich, Germany, 3Philips GmbH Market DACH, Hamburg, Germany, 4School of Medicine, Klinikum rechts der Isar, Department of Psychiatry, Technical University of Munich, Munich, Germany, 5School of Medicine, Klinikum rechts der Isar, Department of Vascular and Endovascular Surgery, Technical University of Munich, Munich, Germany, 6School of Medicine, Klinikum rechts der Isar, Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Klinikum rechts der Isar, Department of Neurology, Munich, Germany
Synopsis
Blood oxygenation level dependent functional connectivity (BOLD-FC) is commonly used as a proxy for neuronal connectivity. Therefore, aberrant BOLD-FC in brain disorders is typically interpreted as aberrant neuronal connectivity. However, beyond changes in neuronal connectivity, impairments in neurovascular coupling (NVC) may also impact on BOLD-FC. This study investigates how impaired local NVC, under conditions of preserved neural functioning, influences BOLD-FC in a sample of unilateral asymptomatic internal carotid artery stenosis patients and healthy age-matched controls. We show that timing aspects of local NVC, namely increased capillary transit time heterogeneity, reduces BOLD-FC, without changes in neuronal functioning.
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