Abstract #2561

Impact of capillary transit time heterogeneity on resting-state BOLD-FC in patients with unilateral asymptomatic carotid artery stenosis

Sebastian Constantin Schneider^1,2, Mario Eduardo Archila-Meléndez^1,2, Jens Göttler^1,2, Stephan Kaczmarz^1,2,3, Jan Kufer^1,2, Benedikt Zott^1,2, Josef Priller⁴, Michael Kallmayer⁵, Claus Zimmer¹, Christian Sorg^1,2, and Christine Preibisch^1,2,6

¹School of Medicine, Klinikum rechts der Isar, Department of Diagnostic and Interventional Neuroradiology, Technical University of Munich, Munich, Germany, ²School of Medicine, Klinikum rechts der Isar, TUM Neuroimaging Center, Technical University of Munich, Munich, Germany, ³Philips GmbH Market DACH, Hamburg, Germany, ⁴School of Medicine, Klinikum rechts der Isar, Department of Psychiatry, Technical University of Munich, Munich, Germany, ⁵School of Medicine, Klinikum rechts der Isar, Department of Vascular and Endovascular Surgery, Technical University of Munich, Munich, Germany, ⁶School of Medicine, Klinikum rechts der Isar, Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Klinikum rechts der Isar, Department of Neurology, Munich, Germany

Synopsis

Blood oxygenation level dependent functional connectivity (BOLD-FC) is commonly used as a proxy for neuronal connectivity. Therefore, aberrant BOLD-FC in brain disorders is typically interpreted as aberrant neuronal connectivity. However, beyond changes in neuronal connectivity, impairments in neurovascular coupling (NVC) may also impact on BOLD-FC. This study investigates how impaired local NVC, under conditions of preserved neural functioning, influences BOLD-FC in a sample of unilateral asymptomatic internal carotid artery stenosis patients and healthy age-matched controls. We show that timing aspects of local NVC, namely increased capillary transit time heterogeneity, reduces BOLD-FC, without changes in neuronal functioning.

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