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Abstract #2569

Dynamic Changes in Functional Network Connectivity Involving Amyotrophic Lateral Sclerosis and Its Correlation With Disease Severity.

LiMin Cai1 and HuaJun Chen1
1Fujian Medical University Union Hospital, Fuzhou, China


We explored dynamic functional network connectivity (dFNC) in ALS and its correlation with disease severity. FNC states were determined by k-mean clustering, and state-specific FNC and dynamic indices (fraction time/mean dwell time/transition number) were calculated. ALS patients showed increased FNC between DMN-SMN in state 1 and between CCN-SMN in state 4. Patients remained in state 2 (showing the weakest FNC) for a significantly longer time and remained in state 1 (showing a relatively strong FNC) for a shorter time. A significant correlation was observed between ALSFRS-R and mean dwell time in state 2 and transition number.

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