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Abstract #2570

Dynamic Functional Connectivity in Pediatric Spinal Cord Injury Patients Versus Healthy Controls

Joseph Schaefer1, Jingya Miao2, Caio Matias2, Feroze Mohamed2, Laura Krisa2, James Harrop2, and Mahdi Alizadeh2
1Neurological Surgery, Thomas Jefferson University, Philadelphia, PA, United States, 2Thomas Jefferson University, Philadelphia, PA, United States


The purpose of this study is to investigate the distributed network properties of subjects with pediatric spinal cord injury using static and dynamic functional connectivity analysis. 36 subjects of which 18 had history of SCI between the ages of 0-18 years underwent 3-Tesla resting state functional MRI (rs-fMRI). Static and dynamic functional connectivity was calculated. Results showed patients with a history of pediatric spinal cord injury did not show widespread changes in static functional connectivity but did have significant changes in dynamic functional connectivity, including spending more time in a relatively hypoconnected brain state and less brain state transitions.

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