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Abstract #2571

Abnormal stability of dynamic functional architecture in amyotrophic lateral sclerosis: a preliminary resting-state fMRI study

Jia Yan Shi1 and Hua Jun Chen2
1Radiology, Fujian Medical University Union Hospital, Fuzhou, China, 2Fujian Medical University Union Hospital, Fuzhou, China


Static and dynamic analyses for identifying functional connectivity(FC)have demonstrated brain dysfunctions in amyotrophic lateral sclerosis(ALS).We are to make the first attempt to perform studies about the stability of dynamic FC analysis based on resting-state fMRI data, in order to provide the new insight into the mechanism in ALS and investigate its correlation with disease severity. Our observation revealed that the abnormal pattern of FC stability involved sensorimotor regions(i.e.left precentral and postcentral gyrus)and non-sensorimotor areas(i.e.right temporal pole and middle/inferior frontal gyrus)in ALS patients, suggesting the potential of functional stability serving as the biomarker for monitoring disease progression in ALS.

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