Frequency, pattern, and associations of renal iron accumulation in sickle/beta-thalassemia
Antonella Meloni1, Luigi Barbuto2, Vincenzo Positano1, Laura Pistoia1, Priscilla Fina3, Giuseppe Peritore4, Michela Zerbini5, Gennaro Restaino6, Calogera Gerardi7, Letizia Tedesco8, Domenico Maddaloni9, Filippo Cademartiri1, and Alessia Pepe1
1Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy, 2Azienda Ospedaliera di Rilievo Nazionale "A. Cardarelli", Napoli, Italy, 3Ospedale "Sandro Pertini", Roma, Italy, 4"ARNAS" Civico, Di Cristina Benfratelli, Palermo, Italy, 5Ospedale del Delta, Lagosanto (FE), Italy, 6Gemelli Molise SpA, Fondazione di Ricerca e Cura "Giovanni Paolo II", Campobasso, Italy, 7Presidio Ospedaliero "Giovanni Paolo II" - Distretto AG2 di Sciacca, Sciacca (AG), Italy, 8Presidio Ospedaliero Locri - A.S.P di Reggio Calabria, Locri (RC), Italy, 9Ospedale "Engles Profili", Fabriano, Italy
Sickle/beta-thalassemia and homozygous sickle cell disease (HbSS) patients were rather similar in respect to hepatic, pancreatic and cardiac iron deposition detected by the T2* MRI technique, but sickle/β-thalassemia patients had significantly less renal iron overload. In sickle/beta-thalassemia renal T2* values were not associated to age, gender, splenectomy, transfusions, serum ferritin levels or iron load in the liver, pancreas and heart, suggesting that performing MRI T2* in other organs is not a reliable approach to predict the exact renal iron state. Renal T2* values were inversely correlated with serum lactate dehydrogenase, confirming that kidney iron results from chronic hemolysis.
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