Sickle/beta-thalassemia and homozygous sickle cell disease (HbSS) patients were rather similar in respect to hepatic, pancreatic and cardiac iron deposition detected by the T2* MRI technique, but sickle/β-thalassemia patients had significantly less renal iron overload. In sickle/beta-thalassemia renal T2* values were not associated to age, gender, splenectomy, transfusions, serum ferritin levels or iron load in the liver, pancreas and heart, suggesting that performing MRI T2* in other organs is not a reliable approach to predict the exact renal iron state. Renal T2* values were inversely correlated with serum lactate dehydrogenase, confirming that kidney iron results from chronic hemolysis.
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