The kidney maintains stable glomerular perfusion and tubular filtration, despite fluctuation in blood pressure. This autoregulation of flow is performed by two key mechanisms: the myogenic response and the tubuloglomerular feedback. Each mechanism is associated with specific but spatially variable bands of low-frequency fluctuations. Mapping autoregulation throughout the kidney could provide new insights into pathophysiology on kidney disease, or provide noninvasive biomarkers to monitor disease. Here we demonstrate the presence of low-frequency fluctuations in the MRI signal in the rat kidney. This work provides new tools for preclinical investigation, and suggests the potential to evaluate kidney autoregulation in clinical setting.
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