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Abstract #2573

Mapping autoregulatory mechanisms in the kidney using resting-state MRI

Darya Morozov1 and Kevin Bennett1
1Radiology, Washington University in St. Louis, St. Louis, MO, United States


The kidney maintains stable glomerular perfusion and tubular filtration, despite fluctuation in blood pressure. This autoregulation of flow is performed by two key mechanisms: the myogenic response and the tubuloglomerular feedback. Each mechanism is associated with specific but spatially variable bands of low-frequency fluctuations. Mapping autoregulation throughout the kidney could provide new insights into pathophysiology on kidney disease, or provide noninvasive biomarkers to monitor disease. Here we demonstrate the presence of low-frequency fluctuations in the MRI signal in the rat kidney. This work provides new tools for preclinical investigation, and suggests the potential to evaluate kidney autoregulation in clinical setting.

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