Testing of Microsatellite Instability (MSI) is used to evaluate the prognosis of endometrial cancer (EC) to make the optimal treatment, and plays an important role to screen for Lynch syndrome. MSI had been detected by the traditional technology, such as PCR, IHC and Next Generation Sequencing（NGS）, however, MSI also could be assessed using magnetic resonance imaging with the advantages of non-invasion and low-cost. This study aimed to investigate the clinical value in assessing the status of EC MSI with amide proton transfer weighted (APTw) imaging and intravoxel incoherent motion (IVIM) diffusion MR imaging.
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