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Abstract #2588

Evaluation of microsatellite instability in endometrial cancer using APTw combined with IVIM MR imaging

Changjun Ma1, Ailian Liu1, Shifeng Tian1, Lihua Chen1, Nan Wang1, Qingwei Song1, and Zhiwei Shen2
1Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian, China, 2Philips Healthy(China), Beijing, China


Testing of Microsatellite Instability (MSI) is used to evaluate the prognosis of endometrial cancer (EC) to make the optimal treatment, and plays an important role to screen for Lynch syndrome. MSI had been detected by the traditional technology, such as PCR, IHC and Next Generation Sequencing(NGS), however, MSI also could be assessed using magnetic resonance imaging with the advantages of non-invasion and low-cost. This study aimed to investigate the clinical value in assessing the status of EC MSI with amide proton transfer weighted (APTw) imaging and intravoxel incoherent motion (IVIM) diffusion MR imaging.

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