Magnetic resonance fingerprinting offers a promising framework by which to rapidly quantify T1rho relaxation alongside other tissue properties such as T1 and T2. However, T1rho-MRF has only recently been reported and sequence optimization remains under-explored, particularly for 3D sequences. Using a digital phantom constructed from real knee tissue property maps, we investigate sequence parameters for a 3D Cartesian T1rho-MRF sequence including preparation pulse scheduling and timing, flip angles, number of readouts, and acceleration factor. T1, T2, and T1rho quantification errors in cartilage and skeletal muscle were evaluated.
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