3D Cartesian T1rho Magnetic Resonance Fingerprinting Sequence Design for Evaluation of Cartilage and Skeletal Muscle in the Knee
Brendan L. Eck1, Jeehun Kim2, Mingrui Yang2, Dan Ma3, Mark A. Griswold3,4, and Xiaojuan Li2,3
1Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, 2Biomedical Engineering, Cleveland Clinic, Cleveland, OH, United States, 3Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 4Department of Radiology, Case Western Reserve University, Cleveland, OH, United States
Magnetic resonance fingerprinting offers a promising framework by which to rapidly quantify T1rho relaxation alongside other tissue properties such as T1 and T2. However, T1rho-MRF has only recently been reported and sequence optimization remains under-explored, particularly for 3D sequences. Using a digital phantom constructed from real knee tissue property maps, we investigate sequence parameters for a 3D Cartesian T1rho-MRF sequence including preparation pulse scheduling and timing, flip angles, number of readouts, and acceleration factor. T1, T2, and T1rho quantification errors in cartilage and skeletal muscle were evaluated.
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