This work implements a method for measuring cerebral kinetics of glucose metabolism using 1H magnetic resonance spectroscopy (MRS) in rats using a small-animal 7T MRI system. The method has been demonstrated to be readily applied to nonhuman primates and human subjects using clinical MRI systems. The extension to small animals requires intravenous administration of small quantities of 13C-labeled glucose, and adaptation of data analysis procedures to data acquired at high magnetic field strength. We demonstrate robust quantification of 13C enrichment within the glutamate at the C4 position. This methodology will facilitate future translational research involving preclinical models of human disease.
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