Meeting Banner
Abstract #2612

1H spectroscopy of glutamate kinetics with 13C-glucose infusion in rodents at 7T

Christopher D. Kroenke1, Natalie M. Zahr2,3, Evan Kittle3, and Adolf Pfefferbaum2,3
1Oregon Health & Science University, Portland, OR, United States, 2Stanford University, Palo Alto, CA, United States, 3SRI International, Palo Alto, CA, United States


This work implements a method for measuring cerebral kinetics of glucose metabolism using 1H magnetic resonance spectroscopy (MRS) in rats using a small-animal 7T MRI system. The method has been demonstrated to be readily applied to nonhuman primates and human subjects using clinical MRI systems. The extension to small animals requires intravenous administration of small quantities of 13C-labeled glucose, and adaptation of data analysis procedures to data acquired at high magnetic field strength. We demonstrate robust quantification of 13C enrichment within the glutamate at the C4 position. This methodology will facilitate future translational research involving preclinical models of human disease.

This abstract and the presentation materials are available to members only; a login is required.

Join Here