Abstract #2613

Monitoring the complexification of cerebellar and thalamic cells during early development with diffusion-weighted MR spectroscopy

Lily Qiu¹, Marco Palombo^2,3, Jason Lerch^1,4,5, and Clémence Ligneul¹

¹Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, ²Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom, ³School of Computer Science and Informatics, Cardiff University, Cardiff, United Kingdom, ⁴Mouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada, ⁵Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada

Synopsis

Monitoring non-invasively the development of brain cells in the neonate and infant brain could be of interest for neurodevelopmental disorders. In this work, we assess whether diffusion-weighted MR spectroscopy (DWMRS) has the potential to follow cerebellar and thalamic cells development in the healthy rat brain from P5 to P30. Results show that DWMRS is sensitive to microstructural changes in the developing brain. The modeling of the data shows a cell growth and complexification (from P15 to P30), and underlies the need of different modeling hypotheses at earlier time points.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.