Monitoring the complexification of cerebellar and thalamic cells during early development with diffusion-weighted MR spectroscopy
Lily Qiu1, Marco Palombo2,3, Jason Lerch1,4,5, and Clémence Ligneul1
1Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 2Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom, 3School of Computer Science and Informatics, Cardiff University, Cardiff, United Kingdom, 4Mouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada, 5Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
Monitoring non-invasively the development of brain cells in the neonate and infant brain could be of interest for neurodevelopmental disorders. In this work, we assess whether diffusion-weighted MR spectroscopy (DWMRS) has the potential to follow cerebellar and thalamic cells development in the healthy rat brain from P5 to P30. Results show that DWMRS is sensitive to microstructural changes in the developing brain. The modeling of the data shows a cell growth and complexification (from P15 to P30), and underlies the need of different modeling hypotheses at earlier time points.
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