Abstract #2618

A meta-analysis of GABA and Glutamate response in functional magnetic resonance spectroscopy

Duanghathai Pasanta^1,2, Georg Oeltzschner³, Talitha Ford⁴, David J. Lythgoe⁵, and Nicolaas A. Puts^1,6

¹Department of Forensic and Neurodevelopmental Sciences, Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom, ²Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand, ³Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Cognitive Neuroscience Unit, School of Psychology, Deakin University, Geelong, Australia, ⁵Department of Neuroimaging, King’s College London, London, United Kingdom, ⁶MRC Centre for Neurodevelopmental Disorders, King's College London, London, United Kingdom

Synopsis

Functional magnetic resonance spectroscopy (fMRS) can be used to investigate the neurometabolic responses to external stimuli in-vivo, but findings to date are inconsistent. We performed a systematic review and meta-analysis on 49 human fMRS studies on Glutamate, Glx (Glutamate + Glutamine) and GABA. Small to moderate effect sizes of 0.29-0.47 (p < 0.05) were observed for Glu/Glx regardless of stimulus domain but not for GABA. Results suggest Glu/Glx and GABA responses vary with time course and are unique to stimulus domain or task. This analysis will inform study design in future work.

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