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Abstract #2618

A meta-analysis of GABA and Glutamate response in functional magnetic resonance spectroscopy

Duanghathai Pasanta1,2, Georg Oeltzschner3, Talitha Ford4, David J. Lythgoe5, and Nicolaas A. Puts1,6
1Department of Forensic and Neurodevelopmental Sciences, Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom, 2Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand, 3Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4Cognitive Neuroscience Unit, School of Psychology, Deakin University, Geelong, Australia, 5Department of Neuroimaging, King’s College London, London, United Kingdom, 6MRC Centre for Neurodevelopmental Disorders, King's College London, London, United Kingdom


Functional magnetic resonance spectroscopy (fMRS) can be used to investigate the neurometabolic responses to external stimuli in-vivo, but findings to date are inconsistent. We performed a systematic review and meta-analysis on 49 human fMRS studies on Glutamate, Glx (Glutamate + Glutamine) and GABA. Small to moderate effect sizes of 0.29-0.47 (p < 0.05) were observed for Glu/Glx regardless of stimulus domain but not for GABA. Results suggest Glu/Glx and GABA responses vary with time course and are unique to stimulus domain or task. This analysis will inform study design in future work.

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