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Abstract #2619

The combined use of MEGA- editing and asymmetric-PRESS methods improve the precision of cerebral lactate detection in healthy adults 

Lauriane Jugé1,2, Iain Ball3, and Caroline D Rae1,2
1Neuroscience Research Australia, Sydney, Australia, 2School of Medical Sciences, University of New South Wales, Sydney, Australia, 3Philips Australia & New Zealand, North Ryde, Australia


Here, we combined two 1H-MRS methods that have shown utility for detecting lactate in the brain, MEGA- editing and use of an asymmetric-PRESS and compared this approach (MEGA-APRESS) with MEGA-PRESS and A-PRESS in phantoms and eight individuals. MEGA-APRESS showed improved precision compared to MEGA-PRESS. Both editing approaches were greatly superior to A-PRESS alone.

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