Here, we combined two 1H-MRS methods that have shown utility for detecting lactate in the brain, MEGA- editing and use of an asymmetric-PRESS and compared this approach (MEGA-APRESS) with MEGA-PRESS and A-PRESS in phantoms and eight individuals. MEGA-APRESS showed improved precision compared to MEGA-PRESS. Both editing approaches were greatly superior to A-PRESS alone.
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