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Abstract #2620

Investigation of metabolic changes in the hippocampus following spinal cord injury applying a metabolite-cycling semi-LASER technique

Sandra Zimmermann1, Dario Pfyffer1, Roland Kreis2,3, Kadir Simsek2,3, Patrick Freund1,4, and Maryam Seif1,4
1Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland, 2Magnetic Resonance Methodology, Institute of Diagnostic and Interventional Neuroradiology, University of Bern, Bern, Switzerland, 3Translational Imaging Center, sitem-insel, Bern, Switzerland, 4Neurophysics Department, Max Plank Institute, Leipzig, Germany


This work uses magnetic resonance spectroscopy data obtained in the hippocampus of 28 patients with traumatic spinal cord injury (SCI) to investigate SCI-induced metabolic changes. Structural magnetic resonance imaging was performed for hippocampal volumetric assessment. Eighteen healthy controls underwent the same imaging protocol. Study participants underwent a functional assessment by testing the visuospatial and verbal memory performance to check for cognitive impairments. In SCI patients without cognitive impairments, hippocampal metabolites did not differ from healthy controls. This study does not support evidence of degeneration and inflammation in the hippocampus of animal models of SCI that show impaired spatial memory performance.

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