This work uses magnetic resonance spectroscopy data obtained in the hippocampus of 28 patients with traumatic spinal cord injury (SCI) to investigate SCI-induced metabolic changes. Structural magnetic resonance imaging was performed for hippocampal volumetric assessment. Eighteen healthy controls underwent the same imaging protocol. Study participants underwent a functional assessment by testing the visuospatial and verbal memory performance to check for cognitive impairments. In SCI patients without cognitive impairments, hippocampal metabolites did not differ from healthy controls. This study does not support evidence of degeneration and inflammation in the hippocampus of animal models of SCI that show impaired spatial memory performance.