One major challenge for 1H-MRSI with localized excitation is minimizing interference from undesired regions, particularly the subcutaneous lipids. In this work, we exploit the complementariness of a new technique called region-optimized virtual coils (ROVir) that is capable of generating a set of virtual channels sensitized to specific regions and spatiospectral processing for lipid removal. Using brain 1H-MRSI data, we demonstrated improved lipid removal by combining ROVir and a state-of-the-art union-of-subspaces method. We expect this integration to be useful for MRSI applications where VOIs are often lateralized (e.g., stroke and tumor) and/or cerebral lipids are of interest.
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