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Abstract #2637

On the basis of sex: Preclinical 23Na MRI at 21.1 T Delineates Sodium Distribution Differences in Females Following Central Sensitization

Samuel W. Holder1,2, Dayna L. Richter1,2, David C. Hike1,2, Michael G. Harrington3, and Samuel C. Grant1,2
1National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, United States, 2Chemical & Biomedical Engineering, FAMU-FSU College of Engineering, Tallahassee, FL, United States, 3Neurology, University of Southern California, Los Angeles, CA, United States

Synopsis

23Na FID-based 3D CSI was implemented in female rats at 21.1 T to examine sex differences in sodium response to NTG-triggered central sensitization. The female brainstem was resilient to NTG-triggered increases in sodium seen with males, despite sodium increases in the female cisterna magna and fourth ventricle. Lateral ventricles and thalamus sodium in females decreased with NTG trigger. Female resilience in brainstem and thalamus, both connected to trigeminal first order neuron, holds interesting implications for migraine.

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