Visual snow syndrome (VSS) is a neurological disorder characterized by continuous visual disturbances, and accompanied by a range of non-visual symptoms, including tinnitus and migraine. Little is known about the pathological mechanisms underlying VSS. In this study we assessed brain morphometry and microstructure in VSS patients using high-resolution structural (MP2RAGE, 0.75 mm iso) and quantitative (T1 mapping) 7T MRI. In VSS patients, we observed similar morphometry, but widespread changes in the grey matter microstructure (lower T1 values), which followed a caudal-rostral pattern affecting the occipital cortices most profoundly. Migraine did not appear to independently affect these changes.
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