BRAIN VOLUMES IN SICKLE CELL DISEASE ACROSS THE LIFESPAN: ALGORITHM PERFORMANCE AND CORRESPONDENCE WITH BLOOD OXYGEN CONTENT
Randall Sky Jones1, Manus Donahue2, Spencer Waddle3, Larry Taylor Davis3, Sumit Pruthi3, Chelsea Lee1, Niral Patel1, Michael DeBaun1, Adetola Kassim4, Mark Rodeghier5, and Lori Jordan1
1Pediatric Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, 2Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, 3Radiology, Vanderbilt University Medical Center, Nashville, TN, United States, 4Medicine; Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN, United States, 5Rodeghier Consulting, Chicago, IL, United States
Brain tissue volumes were calculated in adults and children with sickle cell disease (SCD) across the lifespan for different segmentation algorithms and clinical indicators of disease. Tissue volume reductions in persons with SCD without prior stroke were detected when using FreeSurfer, but not other software, highlighting algorithm bias. Arterial oxygen content was directly related to tissue volumes when using FreeSurfer and SIENAX. Brain tissue volume was not associated with silent cerebral infarcts (SCIs). Findings highlight the subtlety of tissue volume changes in SCD, provide age-specific reference-standards, and motivate an integrated approach of anatomical and functional assessments for informing SCD care.
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