Abstract #2640

Advancing Concussion Assessment in Pediatrics (A-CAP): Longitudinal changes in brain metabolites in pediatric concussion

Parker L La¹, Ashley D Harris¹, Robyn Walker¹, Julie M Joyce¹, Tiffany Bell¹, William Craig², Quynh Doan³, Miriam H Beauchamp⁴, Roger Zemek⁵, Pediatric Emergency Research Canada (PERC)⁶, Keith O Yeates⁷, and Ashley D Harris¹

¹Radiology, University of Calgary, Calgary, AB, Canada, ²Pediatrics, University of Alberta and Stollery Children's Hospital, Edmonton, AB, Canada, ³Pediatrics, University of British Columbia, Vancouver, BC, Canada, ⁴Psychology, University of Montreal and St Justine Hospital, Montreal, QC, Canada, ⁵Pediatrics and Emergency Medicine, University of Ottawa and Children's Hospital of Eastern Ontario, Ottawa, ON, Canada, ⁶University of Calgary, Calgary, AB, Canada, ⁷Psychology, University of Calgary, Calgary, AB, Canada

Synopsis

Disruptions in brain metabolites following concussion are commonly reported in the literature. However, studies have typically included only one timepoint, studied adults and/or had limited sample size. In the largest MRS dataset in pediatric concussion to date, we show that metabolites do not differ significantly over time points with longitudinal data collected sub-acutely (<14 days post-injury) and at 3- or 6-months follow-up. This lack of change may indicate that metabolites are relatively stable, that changes are regionally specific or occur more acutely, or there are subgroups that need to be specifically considered.

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