Advancing Concussion Assessment in Pediatrics (A-CAP): Longitudinal changes in brain metabolites in pediatric concussion
Parker L La1, Ashley D Harris1, Robyn Walker1, Julie M Joyce1, Tiffany Bell1, William Craig2, Quynh Doan3, Miriam H Beauchamp4, Roger Zemek5, Pediatric Emergency Research Canada (PERC)6, Keith O Yeates7, and Ashley D Harris1
1Radiology, University of Calgary, Calgary, AB, Canada, 2Pediatrics, University of Alberta and Stollery Children's Hospital, Edmonton, AB, Canada, 3Pediatrics, University of British Columbia, Vancouver, BC, Canada, 4Psychology, University of Montreal and St Justine Hospital, Montreal, QC, Canada, 5Pediatrics and Emergency Medicine, University of Ottawa and Children's Hospital of Eastern Ontario, Ottawa, ON, Canada, 6University of Calgary, Calgary, AB, Canada, 7Psychology, University of Calgary, Calgary, AB, Canada
Disruptions in brain metabolites following concussion are commonly reported in the literature. However, studies have typically included only one timepoint, studied adults and/or had limited sample size. In the largest MRS dataset in pediatric concussion to date, we show that metabolites do not differ significantly over time points with longitudinal data collected sub-acutely (<14 days post-injury) and at 3- or 6-months follow-up. This lack of change may indicate that metabolites are relatively stable, that changes are regionally specific or occur more acutely, or there are subgroups that need to be specifically considered.
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