Abstract #2644

Dose-dependent response of cerebral blood flow in healthy volunteers following administration of β2-adrenergic receptor agonist clenbuterol

Courtney A. Bishop¹, Thomas Lodeweyckx², Jan de Hoon², Koen Van Laere^3,4, Michel Koole⁴, Wim Vandenberghe⁵, Gaia Rizzo¹, Eugenii Rabiner^1,6, Renee Martin⁷, Anthony Ford⁷, and Gabriel Vargas⁷

¹Invicro, London, United Kingdom, ²Center for Clinical Pharmacology, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium, ³Division of Nuclear Medicine, University Hospital Leuven, Leuven, Belgium, ⁴Nuclear Medicine and Molecular Imaging, KU Leuven, Leuven, Belgium, ⁵Department of Neurology, University Hospital Leuven, Leuven, Belgium, ⁶Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King’s College, London, United Kingdom, ⁷CuraSen Therapeutics, San Carlos, CA, United States

Synopsis

Initial evidence is provided for central effects of the β2-AR agonist clenbuterol on CBF in healthy volunteers. Regions showing particular effect (the hippocampus and thalamus) are associated with cognition and neurodegeneration in Parkinson’s and Alzheimer’s Disease, so similar targeting of β2-AR may prove beneficial in these conditions. Further work is required to determine the extent of central mediation of the effect of β2-AR agonism with clenbuterol in healthy volunteers.

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