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Abstract #2645

A clinical protocol for 3D imaging of the locus coeruleus with super-resolution at 3 Tesla

Catarina Rua1, Mark R Symms2, Ali Ghayoor3, Brian Avants3, Courtney Bishop1, and Lino Becerra3
1Invicro LLC, A Konica Minolta Company, London, United Kingdom, 2GE Healthcare, London, United Kingdom, 3Invicro LLC, A Konica Minolta Company, Needham, MA, United States


The locus coeruleus (LC) is the principal source of noradrenaline production in humans. Histology studies have shown that severe loss of neurons in the LC is associated with many neurodegenerative disorders. Damage is thought to be non-uniform and occurring in stages, hence there is a growing interest in imaging the LC in vivo in these patient populations. In this work we propose a protocol for imaging the LC at clinical field strengths using a 3D magnetization-transfer prepared imaging sequence strategy and the application of super-resolution techniques to increase the LC features within the brainstem region.

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