The aim of this study was to evaluate the clinical feasibility of optimized multi-voxel MR spectroscopic imaging (MRSI) at 3T using rapid symmetric echo-planar spectroscopic imaging (EPSI) spatial encoding in patients with brain tumors. We performed the optimized MRSI at 3T using semi-localization by adiabatic selective refocusing pulses (semi-LASER), fast spatial encoding using symmetric EPSI, and robust water suppression with variable power and optimized relaxation delays. A radiologist with extensive experience in neuroimaging and spectroscopy assessed the overall spectral quality. This study is an attempt to integrate high-resolution MRSI in clinical practice for the assessment of brain cancer patients.
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