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Abstract #2649

Clinical Feasibility of Brain Tumor Multi-voxel MR Spectroscopic Imaging using Rapid Semi-LASER and EPSI Encoding at 3T

Sunitha B Thakur1, Olivia M Sutton2, Almir Bitencourt3, Ralph Noeske4, Tara Fahy1, Ricardo Otazo1, and Robert Young1
1Memorial Sloan Kettering Cancer Center, New York, NY, United States, 2Johns Hopkins Medicine, Baltimore, MD, United States, 3A.C.Camargo Cancer Center, Sao Paulo, SP, Brazil, 4GE HealthCare, Munich, Germany


The aim of this study was to evaluate the clinical feasibility of optimized multi-voxel MR spectroscopic imaging (MRSI) at 3T using rapid symmetric echo-planar spectroscopic imaging (EPSI) spatial encoding in patients with brain tumors. We performed the optimized MRSI at 3T using semi-localization by adiabatic selective refocusing pulses (semi-LASER), fast spatial encoding using symmetric EPSI, and robust water suppression with variable power and optimized relaxation delays. A radiologist with extensive experience in neuroimaging and spectroscopy assessed the overall spectral quality. This study is an attempt to integrate high-resolution MRSI in clinical practice for the assessment of brain cancer patients.

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