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Abstract #2650

Amide proton transfer imaging for differentiation of glioblastoma from brain metastasis

Utarat Kaewumporn1, Doonyaporn Wongsawaeng1, Siriwan Piyapittayanan1, Chanon Ngamsombat1, Panid Chaysiri1, Janiya Kittikornchaichan1, Kritdipha Ningunha2, Nanthasak Tisavipat2, Titima Itthimathin2, Ketkanok Rayaroji2, and Orasa Chawalparit1
1Radiology, Faculty of Medicine Siriraj hospital, Mahidol University, Bangkok, Thailand, 2Bangkok International Hospital, BDMS, Bangkok, Thailand


Until now, the differentiation between glioblastoma and brain metastasis still has some limitations and inconclusive findings.

This study aimed to use amide proton transfer (APT)-weighted imaging to differentiate glioblastoma from brain metastasis.

We found that by quantitative assessment, the APTw value in enhancing solid portion and peritumoral high FLAIR area of glioblastomas were significantly greater than that of brain metastases. The APTw color map also showed higher signal at the peritumoral high FLAIR area in glioblastomas than metastasis by visual assessment.

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