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Abstract #2663

Contrast Enhanced Imaging of Apelin Effects on Vascularization of Orthotopic Glioblastoma in Mice

Geoffrey J. Topping1, Enio Barçi2, Jiying Cheng2, Sandra Sühnel1, Rainer Glass2, Roland E. Kälin2, and Franz Schilling1
1Nuclear Medicine, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany, 2Neurosurgical Research, University Hospital, LMU Munich, Munich, Germany


Mice with orthotopically implanted glioblastoma were imaged during contrast injection, with the goals of establishing semi-quantitative DCE in this model and to investigate the impact of apelin-controlled tumour angiogenesis. Wild-type mice with control U87 tumours showed higher initial contrast accumulation but also faster washout compared to apelin knockout mice implanted with apelin knockdown tumour cells, consistent with apelin contributing to tumour vascularization. Control and apelin knockout mice had low contrast accumulation with genetically engineered human glioma-initiating cells.

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