Meeting Banner
Abstract #2664

Development of noninvasive DCE based method to estimate tumor interstitial Fluid Pressure in Mouse Models for Pancreatic Ductal Adenocarcinoma

Ramesh Paudyal1, Eve LoCastro1, James Russell1, Ivan Wolansky1, Carl C. Lekaye1, Joseph O. Deasy1, John L. Humm1, and Amita Shukla-Dave1,2
1Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 2Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States


Pancreatic cancer accounts for about 3% of all cancer-related deaths in the US. An elevation of interstitial fluid pressure (IFP) is a major barrier to drug delivery in solid tumors. Noninvasive estimation of IFP as a biomarker in typically inaccessible tumors is a significant step toward assessing tumor response to therapy. We applied well-recognized fluid flow in porous media to mouse models of pancreatic ductal adenocarcinoma DCE-MRI data using extended Tofts' model-derived permeability maps with tumor-appropriate tumor geometry. Initial results suggest that after validation, IFP can be imaging biomarkers of early response to therapy.

This abstract and the presentation materials are available to members only; a login is required.

Join Here