The assessment of sexual differences in glioblastoma growth and therapy response has received little attention. We assessed the influence of sex in the MRI features of an orthotropic GBM rat model submitted to anti-inflammatory therapy. Multiparametric MRI studies were acquired at an early and advanced tumor stage of development. GBMs in untreated males presented a more aggressive pattern – worsened as the tumor progressed – than females. While treated males revealed a positive response to meloxicam treatment, females did not. Our results highlighted that sex is a relevant factor to be considered in GBM outcome and anti-inflammatory therapy success.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords