Abstract #2666

Tumor microvasculature and microenvironment characterization in mouse models of pancreatic ductal adenocarcinoma using multiparametric MRI

Ramesh Paudyal¹, James Russell¹, Ivan Wolansky¹, Eve LoCastro¹, Carl C. Lekaye¹, Joseph O. Deasy¹, John L. Humm¹, and Amita Shukla-Dave^1,2

¹Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ²Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States

Synopsis

Pancreatic ductal adenocarcinoma (PDAC) is expected to be the second cause of cancer-related deaths worldwide. Quantitative multiparametric magnetic resonance imaging (mpMRI) provides the complementary physiological properties of tumors tissue. The aim of this study was to characterize microvasculature and microenvironment in mouse models of PDAC using mpMRI. The functional status of mpMRI quantitative imaging metrics were validated with in vivo histology markers of tumor perfusion (Hoechst 33342) and tissue morphology (Hematoxylin and eosin staining).

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