Anatomical, functional and dynamic MRI features of the G144 GBM model developed in NOD-SCID mice
Nuria Arias-Ramos1, Ana M. Cardoso2, Amália S. Jurado2,3, M. Margarida C.A. Castro4, Maria C. Pedroso de Lima2, and Pilar López-Larrubia1
1Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), Madrid, Spain, 2CNC - Center for Neuroscience and Cell Biology, CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, IIIUC - Institute for Interdisciplinary Research, Coimbra, Portugal, 3Department of Life Sciences, University of Coimbra, Coimbra, Portugal, 4Centro de Química de Coimbra, Faculdade de Ciências e Tecnologia, University of Coimbra, Coimbra, Portugal
Preclinical models are needed to study glioblastoma multiforme, the most lethal malignant brain tumor. Human G144-glioblastoma stem cells have been used in in vitro studies but there are few studies in vivo, especially using MRI approaches. We aimed to evaluate in vivo, for the first time to our knowledge, a G144 glioblastoma model by multiparametric-MRI. NOD-SCID mice were orthotopically injected with G144 cells, tumor was characterized by multiparametric-MRI and dynamic contrast enhancement studies. G144 tumors presented heterogeneous imaging pattern compared to other GBM models with higher contrast uptake areas and edema related features.
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