The purpose of this study was to investigate the feasibility of intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) in evaluating early effects of antiangiogenic therapy in a C6 glioma rat model. Twenty-six glioma orthotopic rat models were successfully established 14-16 days after C6 cell inoculation and randomly divided into two groups. The rats in the treated group were administered with Bev while the rats in the control group were administered with vehicle. IVIM-DWI showed significantly decreased D* values and increased ADC and D values corresponding to histological staining in Bev treated tumors.
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