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Abstract #2668

Intravoxel incoherent motion diffusion-weighted imaging for monitoring the anti-angiogenesis efficacy in a C6 glioma rat model

Weishu Hou1, Xiaohu Li1, Hongli Pan1, Man Xu1, Sixing Bi1, Yujun Shen2, Yong Zhang3, Yinfeng Qian1, and Yongqiang Yu1
1the First Affiliated Hospital of Anhui Medical University, Hefei, China, 2Anhui Medical University, Hefei, China, 3GE Healthcare, Shanghai, China


The purpose of this study was to investigate the feasibility of intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) in evaluating early effects of antiangiogenic therapy in a C6 glioma rat model. Twenty-six glioma orthotopic rat models were successfully established 14-16 days after C6 cell inoculation and randomly divided into two groups. The rats in the treated group were administered with Bev while the rats in the control group were administered with vehicle. IVIM-DWI showed significantly decreased D* values and increased ADC and D values corresponding to histological staining in Bev treated tumors.

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